Volunteer: Célia Fortuna Rodrigues
Célia is a PharmD and a Post-Doc at LEPABE – Faculty of Engineering, University of Porto, Portugal. She did her PhD at the Centre of Biological Engineering, in the University of Minho. Her doctoral research focused on Candida glabrata biofilms and the resistance to antifungal drugs. Her work is now dedicated on microorganisms’ detection through microfluidics systems, but she also collaborates in other research works. She has done student supervisions, tutored in classes of biofilm courses and lectured classes. Since December 2017, she regularly contributes to the online Nature Microbiology Community.
The investigation of novel approaches for tackling the antimicrobial resistance crisis must be part of any global response to this problem if an untimely reversion to the pre-penicillin era of medicine is to be avoided. One such promising avenue of research involves so-called antibiotic resistance breakers (ARBs), capable of re-sensitising resistant bacteria to antibiotics. This review introduces the area of ARB research, summarises the current state of ARB development with emphasis on the various major classes of ARBs currently being investigated and their modes of action, and offers a perspective on the future direction of the field.