Volunteer: Goormaghtigh Frédéric
I am a 30-years old post-doc in molecular biology at the Université Libre de Bruxelles (Belgium). During my PhD, I got interested in bacterial persistence, a phenomenon by which very few bacteria transiently operate a phenotypic switch to an antibiotic-tolerant state. I started working on a controversial model in which toxin-antitoxin systems would rule the entry into persistence. We could finally disprove such model after 5 years of intensive research. The question thus remains open: how do some bacteria tolerate extreme doses of antibiotics? We know tackle this question by combining genetics and single-cell microscopy, a very fascinating approach as it allows one to directly observe and analyze how bacteria react to antibiotic treatments. However and because of the long controversy in my field, I understood how important it is to popularize and disseminate the results of scientific research and most importantly to make sure that the information available for non-specialists is of high quality and correct.
FEMS Yeast Research is proud to present this latest thematic issue on yeast pathogenesis and drug resistance. In the past few decades, genetics and genomics studies have uncovered traits underlying the pathogenicity and drug resistances of pathogenic yeast. However, we still have a lot to uncover about the complex mechanisms used by different species to thrive in the human host, and much to do to convert this knowledge into improved clinical treatments. This thematic issue highlights the importance of the diversity of genome-scale approaches to unravel the intricate nature of pathogenesis and drug resistance in pathogenic yeasts, bringing together a diverse range of fascinating views on antifungal drug resistance.