Postdoc on Deciphering Host-Pathogen-Interactions through High-Throughput Genetic Screening: Sweden


Many pathogens have the capacity to invade human cells and to exploit the interior of their host cell as a replicative niche. While human cells have powerful defense programs that can restrict the growth of such invaders, successful pathogens evolved to counteract these defenses. A profound understanding of the molecular basis of this arms race could pave the way for innovative therapeutics. We are currently seeking a postdoctoral researcher for a project that will apply high-throughput genetic screening (e.g. CRISPR/Cas9 screening, siRNA screening, bacterial mutant library screening) to identify key players in host-pathogen interaction, cell-autonomous immunity and immune evasion during infection with the obligate intracellular bacterial pathogen Chlamydia trachomatis.


The Sixt Lab is part of the Laboratory for Molecular Infection Medicine Sweden (MIMS) at Umeå University (located in Umeå, Sweden). MIMS is a part of the Nordic EMBL Partnership for Molecular Medicine and of the Umeå Centre for Microbial Research (UCMR), providing a stimulating, collaborative, and highly international environment with excellent access to modern research facilities. This includes for instance the high-content imaging platforms at the Chemical Biology Consortium Sweden (CBCS) in Umeå. The city Umeå itself combines a rich cultural life with exceptional closeness to nature and is particularly welcoming to internationals.


  • Candidates must hold a University degree equivalent to a European University PhD degree in molecular biology, cell biology, or infection biology (or equivalent fields) at the time of the recruitment. To be eligible, you should have completed your PhD degree a maximum of three years before the end of the application period, unless special circumstances exist.
  • Candidates must have documented practical experience in working with human cell cultures and intracellular bacterial pathogens.
  • Previous experience in molecular genetic manipulation of bacteria and human cells, genetic screening approaches and fluorescence microscopy is required.
  • Candidates should be passionate about science, willing to take on scientific challenges, and committed to highest quality research.
  • Candidates are expected to be proficient in written and spoken English, to work as part of an interactive team, to participate in the mentoring of less experienced team members, and in particular to have the capacity to individually develop and drive a research project.

Project duration: 2 years (with possibility for further prolongation depending on satisfactory performance)

Starting date: preferentially fall 2021 (can be negotiated)

Application: You can apply through the Umeå University recruitment system. The application portal closes August 16, 2021.

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