The University of Gothenburg is seeking to fill the position of Postdoctoral fellows on a subject of “Yeast as a model for aging and age-related proteoptahies”.

Subject area description

This project aims to decipher how yeast cells manages misfolded proteins, including human disease proteins, through their protein quality control systems (PQC) in different irganelles and how these systems communicate with each other. Further, the project will analyze how cellular aging is affecting the activity of these systems and how this, in turn, may influence the buildup of cytotoxic aggregates, including model disease proteins of human neurological disorders, during cellular aging.

Job assignments

The postdoctoral project consists of research and supervision. The research entails in-depth analysis of yeast PQCand protein aggregation using molecular, genetic, and biochemical tools. Microscopy including single-cell, as well as, ensemble analysis is a prominent part of the assignment. The project will also include the construction of new yeast strains suitable for microscopic analysis of protein aggregation and new genetic screens.

Eligibility

An achieved doctoral degree is compulsory for a position as postdoctor at Göteborg University. The doctoral thesis shall be in a relevant area according to the specific position stated here. Since a position as postdoctor aims to give new holders of the doctorate the opportunity mainly to strengthen and develop their scholarly proficiency, we aim for those who have a doctoral degree not older than 3 years counting from last date of application.The qualifications for academic positions are given in Chapter 4, Section 3 – 4 of the Higher Education Ordinance.

Assessment

We are looking for a scholar with well-documented merits in yeast (Saccharomyces cerevisiae) molecular biology, including genetics and strain constructions. The successful applicant should have experience in microscopy including single-cell analysis. Documented (peer-reviewed original papers) expertise in working with yeast protein quality control/protein aggregation is considered advantageous.Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 – 4 of the Higher Education Ordinance.

Employment

The employment is fulltime and temporary, two years, with placement at the Institute of Biomedicine.

For further information

Please contact professor Thomas Nyström, e-mail: thomas.nystrom@cmb.gu.se