The Francis Crick Institute  is looking for a  Senior Laboratory Research Scientist to work for the research group “Host-pathogen interactions in tuberculosis”. This role is critical to generate tools and perform experiments in CL2/CL3 labs as well as training of new people joining the group. This role requires substantial experience in mycobacterial genetics and/or stem cell culture/CRISPR/Cas9 targeting. Experience in imaging and image analysis is desirable. This role reports to Max Gutierrez.

PROJECT SUMMARY

Our group is interested in the area of cellular microbiology of M. tuberculosis with a focus on the innate immune system and phagocytosis. In particular, we are interested in understanding how M. tuberculosis survive within host cells and the mechanisms that host cells use to eliminate intracellular M. tuberculosis.

The position has been created to ensure the successful implementation of a research project funded by the European Research Council (ERC) that aims to develop imaging tools to better understand the complex interactions between M. tuberculosis and human macrophages.

KEY RESPONSIBILITIES

These include but not limited to;

• Running CL2 (BSL2) and CL3 (BSL3) laboratories
• Responsible for training and assisting people in CL2 and CL3 laboratories
• Conducting and presenting experimental work, keeping accurate records
• Organisation and maintenance of laboratory supplies and equipment
• Generation, organisation and maintenance of genetically modified mycobacteria
• Stem cell culture (iPSC) and CRISPR/Cas9 gene targeting