Metabolic signaling is at the intersection of many scientific fields, ranging from basic biochemistry and molecular biology to physiology and pathophysiology. Currently, a major challenge for these disparate fields is to define commonalities and differences in the function and regulation of metabolism, and determine the role of metabolic signals in normal physiology as well as disease states. This meeting will fill an important gap by bringing together outstanding researchers with a common goal of understanding the role and regulation of metabolic signals in a diverse array of pathways, cell types, and diseases.