This course, organized by Institut Pasteur,  is designed for early career scientists – assistant professors, new industry scientists, MDs, and postdoctoral research associates – as well as members from developing areas contending with the practical challenge of managing the antibiotic resistance problem with limited resources. Attendance will be limited to 40 students and will reflect the global nature of the problem.

The faculty is composed of 40 internationally recognized scientists and physicians who have made important contributions to antibiotic development, and infectious diseases and resistance management. Faculty will be in residence for a minimum of two days and  accessible for informal interactions. Graduates will emerge with a state-of-the-art understanding of existing antibiotics: modes of action, pharmacology, toxicology, mechanisms of resistance, impact of antibiotics on human and other ecologies, current approaches for mining chemical space for antimicrobial activity, the process of advancing hits to leads, the application of next generation nucleic acid-based technologies for antibiotic discovery and resistance detection, and perhaps, most importantly, training and experience in thinking creatively and innovatively about solutions to the problem. The course aims to build an international cadre of collaborative, well networked, and highly trained specialists.

THE THEMES OF THE CONFERENCES

Current infectious disease management and antibiotic use

Modes of action and mechanisms of resistance of existing classes : Cell wall, Ribosome, Nucleic acid synthesis / replication / transcription, Efflux

Origin, mutations, and identifications of antibiotic resistance mechanisms

Antibiotic discovery

Antibiotic chemical matter : Natural products, synthetics

Antibiotic development and approval

New topics in antibiotic discovery

Strategies for more focused applications of antibiotics

New technologies for determination of susceptibility and detection of resistance

New antiinfective strategies

THE THEMES OF THE PRACTICAL WORK

Choosing the DNA sequencing technology

Data bases for antibiotic resistance and virulence

Detection and identification of resistance genes

Mobile genetic elements

TnSeq, RNASeq

Functional genomics

Phylogeny

The course will be administered over 8 days and will consist of formal instruction, review of the literature, small group problem solving including hands-on use of relevant computational tools, innovation-driven brainstorming sessions, and network building.

Pratical Information:

Place: Les Pensières, Annecy, France

Dates:  6-14 October 2018

Application deadline: 15 May 2018

Language: English

Diploma: Institut Pasteur Diploma