Applications are invited for a postdoctoral position in the group of Taras Nazarko studying mechanisms of lipophagy, the selective autophagy of lipid droplets (LDs). Lipophagy is accomplished by delivery of LDs from the cytosol to the lysosome (or vacuole in yeast). As in other autophagic pathways, the core autophagic machinery forms the autophagic isolation membrane that sequesters the LD from the cytosol. However, how this autophagic membrane recognizes the LD after lipophagy was induced is unknown. Also, it is not clear how lipophagy is kept in check the rest of the time. Therefore, lipophagy selectivity and regulation are the key gaps in our understanding of this pathway.

• A postdoctoral scholar will develop a project in one of these areas
• Mechanistic understanding in these areas is critical for the precise control of lipophagy in humans for the prevention and treatment of various lipid accumulation diseases, like atherosclerosis and obesity
• Initial appointment is for 1 year with possible extension for up to 5 years of overall postdoctoral training
• Salary is commensurate with the Experience Level

Applicant requirements

• The successful applicants will have a recent PhD in biochemistry, genetics, molecular or cell biology and a strong background in yeast genetics, protein biochemistry and fluorescence microscopy
• Expertise with mammalian cells or zebrafish model is a plus but not essential
• Preference will be given to candidates with experience in autophagy or lipid droplets

How to apply

Please send your cover letter, CV and contact information of 3 references to Taras Nazarko (tnazarko@ucsd.edu)