Applications are invited from outstanding and highly motivated candidates for a fixed term position as postdoctoral researcher in in the Molecular Medicine laboratory of Professor Santocanale, Centre for Chromosome Biology at the National University of Ireland, Galway. This position is funded by Science Foundation Ireland (SFI) and is available for up to three years to project end date of 31^st October 2021, subject to initial one year probationary period.  The project will investigate novel roles of the Cdc7 kinase in human cells. Cdc7 kinase is a key regulator of DNA replication and cell cycle progression and inhibition of Cdc7 is an emerging strategy for the treatment of human cancers. In particular this project will aim to define the reciprocal roles of the two cellular Cdc7 complexes, Cdc7/Dbf4 and Cdc7/Drf1, by defining their reciprocal cellular localization, by identifying novel substrates and by conducting large-scale genome wide loss of function synthetic lethality screenings.

Job Description:

The successful candidate will perform research to dissect molecular mechanisms of DNA replication and cell division.

Duties:

• conduct research independently under the supervision of the Principal Investigator and collaboratively with local and international collaborators
• co-supervision of postgraduate and undergraduate students
• keep up to date with and development of research related methods and techniques
• complete the administrative work to support the programme of research.

Qualifications/Skills required: 

Essential Requirements:

• PhD in Biochemistry, molecular genetics or closely related discipline
• evidence of a strong background in molecular biology and cell biology techniques
• comprehensive knowledge of cell cycle regulation, DNA replication and cell-cycle checkpoints
• evidence of specific experience with fluorescence microscopy and flow cytometry techniques
• demonstrable expertise in either genomics, bioinformatics or proteomics
• computer skills including, Microsoft office package
• ability to work and think independently
• excellent writing and oral communication skills
• excellent organizational skills
• high levels of initiative
• track-record of peer-reviewed publications in the field. 

Desirable Requirements:

• specific expertise with DNA replication assays
• specific expertise electron microscopy of small molecules
• knowledge of centrosome duplication cycle.

To Apply:   applications to include a covering letter, CV,and the contact details of three referees should be sent, via e-mail (in word or PDF only) to Professor Corrado Santocanale at corrado.santocanale@nuigalway.ie