“To raise new questions, new possibilities, to regard old problems from a new angle, requires creative imagination and marks real advance in science.”—Albert Einstein
FEMS is leading the way in promoting excellence and diversity in science, and in channelling high quality knowledge to solving today’s societal problems around microbiology. It does this by funding research, publishing journals, organizing events, facilitating collaborative projects and developing strong partnerships with other, likeminded organizations.
The aim of this study was to determine whether in vitro induced erythromycin resistance facilitates the cross-resistance to the novel fluoroketolide, solithromycin, in Staphylococcus aureus. Long-term exposure of erythromycin results in resistance to ketolides in S. aureus through drug binding site mutations. These results demonstrate that since erythromycin has been used clinically for a long time, it is necessary to carefully evaluate the rewards and risks when prescribing solithromycin for the treatment of infectious diseases.