“To raise new questions, new possibilities, to regard old problems from a new angle, requires creative imagination and marks real advance in science.”—Albert Einstein
FEMS is leading the way in promoting excellence and diversity in science, and in channelling high quality knowledge to solving today’s societal problems around microbiology. It does this by funding research, publishing journals, organizing events, facilitating collaborative projects and developing strong partnerships with other, likeminded organizations.
The investigation of novel approaches for tackling the antimicrobial resistance crisis must be part of any global response to this problem if an untimely reversion to the pre-penicillin era of medicine is to be avoided. One such promising avenue of research involves so-called antibiotic resistance breakers (ARBs), capable of re-sensitising resistant bacteria to antibiotics. This review introduces the area of ARB research, summarises the current state of ARB development with emphasis on the various major classes of ARBs currently being investigated and their modes of action, and offers a perspective on the future direction of the field.