Linköping University hereby advertises a position as Postdoc in Genome integrity and Telomere Biology formally based at the Department of Medicine and Health. 

Work field
The integrity of our DNA is continuously threatened by both endogenous and exogenous sources of damage, which have the potential to give rise to mutations and chromosome rearrangements. Eukaryotic cells have evolved DNA Damage Response pathways to recognize and repair such damage. Defects in these pathways promote genome instability, tumorigenesis, and cancer progression. At the same time, the linear, eukaryotic chromosomes are at risk of being mistaken as sites of DNA damage and failure in protecting telomeres from the DNA Damage Response pathways has also been associated with genome instability and tumor progression.

The Lottersberger’s research team (https://liu.se/en/employee/fralo26) uses a variety of approaches including live-cell imaging, telomere detection assays, and chromosomal rearrangement analysis combined with genetic approaches to address key questions in the field of genome stability, chromatin mobility and telomere maintenance, with the ultimate goal of identifying new targets for cancer treatment and tailoring targeted therapies for specific life-threatening cancers.

The postdoc position is at the Division of Drug Research at the Department of Medicine and Health. The division conducts research and education in the field of pharmacology, both preclinical and clinical. 

Duties
The candidate will be fully responsible for a research project in genome stability. The position requires genetic approaches combined with quantitative live-cell imaging, mass spectrometry-based screening, telomere detection assays, and chromosomal rearrangement analysis in order to dissect the molecular pathways that encompass DNA Damage Response, chromatin mobility, nuclear structure and/or telomere metabolism in both mouse and human cell lines.

The candidate will be expected to publish the scientific results in peer-reviewed journals and present data at international conferences.

A Postdoc will essentially carry out research. The position may also involve teaching, but during no more than a fifth of work time. 

Qualifications
We are looking for a talented, highly motivated, and creative candidate with a doctorate or an equivalent degree from a foreign university in the field of cell and molecular biology or related disciplines. Preference will be given to applicants with theoretical and practical knowledge of chromosome biology, DNA damage response and telomere homeostasis. Previous experiences in cell culture, CRISPR-Cas9 gene editing, ChIP assay, and imaging are a merit.

Good communication and writing skills in English are required.