FEMS Yeast Research Poster Prize: Valentina del Olmo Toledo
We send our congratulations to Valentina del Olmo Toledo, who won the best poster prize at the 9th Advanced Lecture Course on Human Fungal Pathogens. This award is sponsored by our journal FEMS Yeast Research.
The 9th Advanced Lecture Course on Human Fungal Pathogens (FEBS2022) was held on the 14-20 May 2022 in France. This was a FEMS Sponsored Event and FEMS supported Early Career Researchers with travel grants to attend this course.
Read our interview with Valentina about her research below:
What is your current position, and what was your scientific journey to get there?
I am currently part of the Comparative Genomics group led by Toni Gabaldón, affiliated to both the Barcelona Supercomputing Center (BSC) and the Biomedical Research Institute (IRB) in Barcelona. I did most of my training in Germany, I obtained a MSc degree at the Heinrich-Heine-Universität of Düsseldorf and then moved on to do my PhD work at the Institute of Molecular Infection Biology (IMIB) in Würzburg (Germany). There, as part of Christian Pérez’s group, I studied the evolution of transcriptional regulatory networks in the fungal pathogen Candida albicans.”
Could you describe the research your poster covered?
I am interested in how pathogenic fungal lineages emerge and particularly in the role that hybridisation plays in this process. Hybridisation is common in yeasts and often leads to genomic variability and adaptation. Candida orthopsilosis is a human-associated opportunistic pathogen and most clinical isolates are hybrids resulting from crosses between two parental lineages of which only one has been identified. The rare presence or total absence of parentals amongst clinical isolates is hypothesised to be a consequence of a reduced pathogenicity with respect to their hybrids. In my poster, I presented the genome analysis of the first sequenced environmental C. orthopsilosis strains, which were isolated from warm marine ecosystems. I found that the majority of environmental isolates are hybrids, and that these are phylogenetically closely related to hybrid clinical isolates. Furthermore, I identified the long-sought missing parental lineage, thus providing a complete overview of the genomic evolution of this species. The results suggest a marine origin of C. orthopsilosis hybrids and pave the way to identifying the pre-existing environmental adaptations that rendered hybrids more prone to colonising and infecting the mammalian host.”
What do you hope to focus your research on in the future?
I am currently fascinated by these pathogenic hybrid yeasts and I would like to continue contributing to expand the knowledge on fungal hybrid species. There are still many aspects of their genomes, ecology and evolution that are not yet understood, as well as numerous parental lineages that remain to be discovered.”
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FEMS Yeast Research is proud to present this latest thematic issue on yeast pathogenesis and drug resistance. In the past few decades, genetics and genomics studies have uncovered traits underlying the pathogenicity and drug resistances of pathogenic yeast. However, we still have a lot to uncover about the complex mechanisms used by different species to thrive in the human host, and much to do to convert this knowledge into improved clinical treatments. This thematic issue highlights the importance of the diversity of genome-scale approaches to unravel the intricate nature of pathogenesis and drug resistance in pathogenic yeasts, bringing together a diverse range of fascinating views on antifungal drug resistance.