Programme

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Content

The content of the Summer School will be focused on the following theme:

BIOLOGICAL ROBUSTNESS: EVOLUTION OF BACTERIAL RESISTANCE TO DEATH

The FEMS Summer School will explore common strategies and particular mechanisms of bacterial resistance to death under extreme conditions, e.g., desiccation, extreme temperatures, salinity, generally toxic chemicals, radiation, antibiotics and immunity.

When facing lethal challenge by extreme conditions, bacteria have evolved two main solutions:

  • Extremophilia, which converts extreme conditions into optimal conditions by biological adaptation
  • Robustness, which is cellular capacity to resuscitate after “clinical death” caused by excessive biological damage

The success of either of the two evolutionary strategies requires sufficient residual proteome activity to (i) allow for the continuity of the adaptive evolutionary process and (ii) to trigger the snowballing of molecular renewal and repair processes resulting in survival.

Therefore, the first FEMS Summer School will:

  • review the plethora of lethal treatments to which certain bacteria evolved extreme resistance
  • seek for most upstream cause of bacterial death common to all lethal treatments
  • search for potential common mechanism(s) of bacterial death
  • explore the means of proteome protection and defence that allows robust bacteria to resist deadly challenges in natural and hospital environments
  • explore mechanisms by which inter-cellular communication in bacterial communities improves survival of individual cells

While being primarily a school, substantial free time and an informal and cosy environment and atmosphere will facilitate academic and networking interactions between all attendees.

 

Programme

The final day by day programme for the FEMS Summer School for Postdocs.

Day 1 – Wednesday, August 28

Registration – Arrival of attendees

17h00: Opening remarks

  • Prof. Miroslav Radman (30min)
  • Prof. Graham Walker (30min)

18h00: FEMS President, Prof. d-r Bauke Oudega (20min)

18h25: FEMS Director of events and Internationalization, Prof. d-r Vaso Taleski (20min)

18h45: Students Presentations (first half) – 1h10

20h00: Dinner

 

Day 2 – Thursday, August 29

9h00: Students Presentations (second half) – 1h10

10h10: Coffee Break

10h30:

Graham Walker

  • Bacterial responses to DNA damage: Roles of translesion DNA synthesis.

12h00:

Ivan Matic

  • Impact of the subinhibitory concentrations of antibiotics on bacteria

13h30: Lunch

14h30:

Suzanne Sommer

  • Deinococcus response to radiations (IrrE, DdrO, DrRRA, DdrI, LexA)

16h00:

Ksenija Zahradka (45min)

  • Double-strand DNA break repair and genome rearrangements in Deinococcus radiodurans

16h50: Coffee Break

17h10: Meet the Mentors

 

Day 3 – Friday, August 30

9h00:

Suzanne Sommer

  • DNA double strand break repair, chromosome segregation and restoration of cell division (SSA, ESDSA, HR and our recent work on PprA and RecN)

10h30: Coffee Break

10h45:

Davor Zahradka (45min)

  • RecBCD- RecFOR-independent pathway of homologous recombination in Escherichia coli.

11h30: Meet the Mentors

13h00: Lunch

14h30:

Thomas Nystrom

  • Finding genes required for cellular rejuvenation

16h00:

Fernando Baquero

  • The resistomes

 

Day 4 – Saturday, August 31

9h00:

Graham Walker

  • Complexities of bacterial cell death from antibiotics and certain other stresses.

10h30:

Ivan Matic

  • Evolution of mutation rates in bacteria

12h00: Coffee Break

12h15: Meet the Mentors

13h30: Lunch

14h30:

Fernando Baquero

  • Multi-level population biology of antibiotic resistance

16h00:

Thomas Nystrom

  • Deciding between death or longevity; a metacaspase case study

 

Day 5 – Sunday, September 1st

Day trip – Free Day

 

Day 6 – Monday, September 2nd

9h00:

Anita Krisko: Talk 1

10h30: Coffee Break

11h00: Meet the Mentors Day

13h00: Lunch

14h30:

Meet the Mentors day (2h)

16h00: Free evening

 

Day 7 – Tuesday, September 3rd

9h00:

David Sherratt

  • Managing a chromosome; replication, recombination-repair and unlinking

10h30: Coffee Break

10h50:

Anita Krisko: Talk 2

13h00: Lunch

14h30:

Branka Bernard

  • Interactive Workshop on Writing Grant Proposals

 

Day 8 – Wednesday, September 4th

9h00:

David Sherratt

  • Managing a bacterial chromosome; organisation, individualisation and segregation by SMC complexes

10h30: Round Table (+ Formation of groups for project proposal)

13h00: Lunch

14h30:

Patrick Bavoil – FEMS Director of Research and Publications (45min + 45min of discussion)

16h00: Preparation of Project Proposals

 

Day 9 – Thursday, September 5

10h00:

Discussion groups: Anita Krisko, David Sherratt, and Miroslav Radman

13h00: Lunch

14h30:

Presentation Project Proposals (first half)

 

Day 10 – Friday, September 6

11h00: Presentation Project Proposals (Second Half)

13h30: Lunch

14h30: Closing Remarks + Announcement of Best Project Proposal

 

Day 11 – Saturday, September 7

Departure Day

 

Mentors and Speakers

Prof. Miroslav Radman – FEMS-Lwoff Award winner (2011) for his research of DNA repair mechanism in Deinococcus radiodurans, Fellow of French Academy of Sciences, Corresponding member of Croatian Academy of Arts and Sciences, Foreign honorary member of American Academy of Arts and Sciences, Member of The Academy of Europe – Co-founder of MedILs and Co-Director of Summer School

 

 

Prof. Graham Walker – Director of Walker Lab, MIT, American Cancer Society Professor; HHMI Professor; MacVicar Faculty Fellow – Co-Director of Summer School

  • Presentation 1): Bacterial responses to DNA damage: Roles of translesion DNA synthesis
  • Presentation 2): Complexities of bacterial cell death from antibiotics and certain other stresses

 

Prof. Ivan Matic – Director of Ta Ma Ra lab, Paris Descartes Medical Faculty – Co-Founder of MedILS

  • Presentation 1): Impact of the subinhibitory concentrations of antibiotics on bacteria
  • Presentation 2): Evolution of mutation rates in bacteria

 

Prof. David Sherratt – Leader of Sherrat Lab, Department of Biochemistry, University of Oxford – Iveagh Professor of Microbiology

  • Presentation 1): Managing a chromosome; replication, recombination-repair and unlinking
  • Presentation 2): Managing a bacterial chromosome; organisation, individualisation and segregation by SMC complexes

 

Prof. Suzanne Sommer – Institut de Génétique et Microbiologie (IGMORS), Université Paris-Sud

  • Presentation 1): Deinococcus response to radiations (IrrE, DdrO, DrRRA, DdrI, LexA) 
  • Presentation 2): DNA double strand break repair, chromosome segregation and restoration of cell division (SSA, ESDSA, HR and our recent work on PprA and RecN)

 

Prof. Thomas Nyström – Principal Investigator, Nyström Lab, Department of Microbiology and Immunology at Institute of Biomedicine, University of Gothenburg – Member of the Royal Swedish Academy of Sciences, Class VI, the American Academy of Microbiology, the American Society for Biochemistry and Molecular Biology, and EMBO

  • Presentation 1): Finding genes required for cellular rejuvenation
  • Presentation 2): Deciding between death or longevity; a metacaspase case study

 

Prof. Fernando Baquero – Founder, former Director, and currently a Research Professor in the Department of Microbiology as well as Scientific Director of the Ramón y Cajal Institute for Research in Biomedicine at the Ramón y Cajal University Hospital in Madrid, Spain – Member of CIBERESP and Associated Scientist at the Astrobiology Center (CSIC) in Madrid

  • Presentation 1): The resistomes
  • Presentation 2): Multi-level population biology of antibiotic resistance
  • Presentation 3): One-Health and Global-Health issues in antibiotic resistance

 

Dr. Ksenija Zahradka – Senior Research Associate, Ruđer Bošković Institute (IRB) Zagreb

  • Presentation 1):  Double-strand DNA break repair and genome rearrangements in Deinococcus radiodurans
  • Presentation 2): RecBCD- RecFOR-independent pathway of homologous recombination in
    Escherichia coli.

Dr. Anita Krisko – Junior Group Leader, MedILS – UNESCO-L’Oreal prize winner ˝For Women in Science˝

Dr. Davor Zahradka – Senior Research Associate, Ruđer Bošković Institute (IRB) Zagreb

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