Microbes and Us Podcast Episode 27: Article Award Winner, Pathogens and Disease: GBP recruitment in Francisella novicida and Shigella flexneri


Let’s talk about the comparative study of GBP recruitment on two cytosol-dwelling pathogens! In this episode, host, Joseph Shuttleworth learns from Pathogens and Disease Article Award winners from 2023, Manon Degabriel & Thomas Henry for their work on Guanylate-Binding Proteins (GBPs).

What are GBPs? These proteins play a crucial role in the immune system’s fight against pathogens that take up residence inside our cells.

The winning research: Manon Degabriel & Thomas Henry compared how GBPs interact with two nasty bacteria: Francisella novicida and Shigella flexneri.  Their research revealed differences in how GBPs tackle each bacteria.

Why this matters: This discovery opens doors for developing new therapies that target GBPs specifically for each type of infection.

Discussion points: 
  • Break down the role of GBPs in the immune system.
  • Outline the key differences between the way these two species interact.
  • Dive deeper into the differences found in GBP recruitment.
  • What are the next steps for this exciting research avenue?

Join us as we hear from our expert authors as they dive into the world of Guanylate-Binding Proteins (GBPs), interferon-inducible GTPases that play a key role in cell autonomous responses against intracellular pathogens, such as Francisella novicida and Shigella flexneri.

Tune in here

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